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Border Collie Health Issues: A Short List Worth Knowing

Border Collies are generally hardy and long-lived, but a handful of inherited conditions run in the breed: an eye defect called Collie eye anomaly, epilepsy, hip dysplasia and a digestive condition (EPI). The MDR1 drug-sensitivity gene is much rarer in Border Collies than in other herding breeds, but a test still settles it. This guide is general information, not veterinary advice.

9 min read · Updated October 8, 2026
Author: LocalPetFinder Team

The short answer

Ask your vet for an eye exam and a conversation about genetic tests for Collie eye anomaly and MDR1. Learn what a seizure looks like and when it becomes an emergency. Keep the dog lean for its hips, and report weight loss despite a big appetite. If your dog wobbles or collapses during hard exercise, stop and see your vet. Price pet insurance in your first week.

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A black and white Border Collie outdoors, focused and alert
Border Collies are generally hardy; a few genetic tests answer most of the remaining questions.

Collie eye anomaly

Collie eye anomaly is an inherited defect in how the back of the eye develops. VCA Animal Hospitals names the Border Collie among the affected breeds. Many dogs have mild changes that never affect daily life, but more severe forms can lead to retinal detachment and vision loss.

Several genetic tests exist, and an eye exam by your vet or a veterinary ophthalmologist shows how a particular dog is affected. If your dog suddenly seems unsure in dim light or bumps into things, book an eye check promptly, since early laser treatment can help some retinal detachments.

Epilepsy

Border Collies are on VCA’s list of breeds with a higher rate of epilepsy and a suspected genetic basis. Most seizures last 30 to 90 seconds. Keep your hands away from the mouth, move furniture away, time the seizure and call your vet afterwards.

A seizure that will not stop, or seizures that follow one another closely, is an emergency. Many epileptic dogs live full lives on daily medication your vet prescribes and monitors.

Browse adoptable Border Collies

Foster notes often mention eye checks, seizures or energy level, which is exactly what to raise at your first vet visit.

See Available Border Collies →

MDR1: rarer than you might think

The MDR1 mutation makes some dogs dangerously sensitive to certain common medications. It is famous in herding breeds, but Washington State University lists Border Collies at under 5%, compared with about 70% of Collies and 50% of Australian Shepherds.

That is low, not zero, and many rescue Border Collies are crosses whose background is unknown. A cheek-swab test gives a clear answer once, and the result belongs in your dog’s file so every vet sees it.

Hips, EPI and exercise collapse

Hip dysplasia occurs in active, medium-sized breeds; keeping the dog lean and building fitness gradually protect the joints. Exocrine pancreatic insufficiency, in which the pancreas stops making digestive enzymes, is another condition VCA lists for Border Collies. The sign is weight loss despite a big appetite, with large, pale stools; lifelong enzyme replacement manages it well.

The Merck Veterinary Manual notes a collapse syndrome in Border Collies during intense exercise, for which no gene has yet been found. A dog that becomes wobbly, disoriented or collapses during hard work should stop, cool down and see a vet, who will also rule out heat stroke.

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The first vet visit after adoption

Ask for an eye exam, a gait and hip assessment, a body condition score and a conversation about genetic testing for Collie eye anomaly and MDR1. Mention any seizure history in the rescue’s notes. Bring the rescue’s records.

Price pet insurance the same week. Every Canadian provider excludes conditions documented before enrolment, and epilepsy is a lifelong cost that insurance can help with if it is not already on file.

Frequently asked questions

What are the most common Border Collie health issues?

Collie eye anomaly, epilepsy, hip dysplasia, exocrine pancreatic insufficiency, an exercise-related collapse syndrome and, in a small share of dogs, MDR1 drug sensitivity.

Do Border Collies have the MDR1 gene?

Some do, but far fewer than Collies or Australian Shepherds. Washington State University lists Border Collies at under 5%. A cheek-swab test gives a definite answer.

What is Collie eye anomaly?

An inherited defect in the development of the back of the eye. Mild forms rarely affect vision; severe forms can lead to retinal detachment. Genetic tests and an eye exam tell you where your dog stands.

What should I do if my Border Collie has a seizure?

Keep calm, keep your hands away from the mouth, move objects away and time it. Call your vet afterwards. A seizure that does not stop, or several in a row, is an emergency.

How long do Border Collies live?

They are a generally long-lived breed, often into their teens, with good weight control, exercise and regular checkups.

Should I get pet insurance for a rescue Border Collie?

It is worth pricing in your first week. Canadian pet insurance excludes conditions documented before enrolment, and epilepsy or eye problems are easier to insure before they are diagnosed.

Sources

General information, not veterinary advice. Diagnosis and treatment decisions belong with your veterinarian.

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